Previous studies have observed that invasive Paget cells demonstrated lower E-cadherin expression and higher expression of mesenchymal markers including N-cadherin and/or vimentin than normal epidermal keratinocytes and in situ carcinoma Paget cells, and the expression of EMT-related markers correlated with the incidence of lymphatic invasion in primary skin tumor [43, 45]. This evidence concerns the gene CDH1 and in situ carcinoma.