TP53 and cancer: On the one hand, the nodes included in module 1 of the subnetwork A were associated with Cell cycle, Cellular senescence, p53 signaling pathway, Viral carcinogenesis, and Pathways in cancer; on the other hand, ErbB signaling pathway, EGFR tyrosine kinase inhibitor resistance, Focal adhesion, Ras signaling pathway, and Proteoglycans in cancer in module 2; and finally, Transcriptional misregulation in cancer, Thyroid hormone signaling pathway, Pathways in cancer, Signaling pathways regulating pluripotency of stem cells, and Adherens junction in module 3.