GSDMD and systemic lupus erythematosus: Notably, when screening for changes in immune cell subsets in the spleens of lupus mice, we found that loss of GSDMD did not make a difference in total B cells, T cells differentiation into T helper (Th1, Th2, and Th17) or Treg cells, as well as the type I interferon-producing plasmacytoid dendritic cells (pDCs) (data not shown), indicating that GSDMD likely does not act through these lymphocytes and pDCs.