Unexpectedly, myeloid pyroptosis was not increased with elevated and activated GSDMD during LN, represented as the comparable percentages of caspase-1/11+PI+ cells or caspase-1/11+Hoechst+ cells gated on CD11b+ cells in the kidneys of lupus mice and their controls (Fig. 2—figure supplement 1B-C). The gene discussed is ITGAM; the disease is systemic lupus erythematosus.