Paradoxically, recent follow-on studies found that neutrophils-specific GSDMD deficiency or administration of the GSDMD inhibitor disulfiram/Ac-FLTD-CMK alleviated disease severity in pristane-induced lupus model, in which the assembly of GSDMD pores promoted NETs formation [14, 17, 18]. Here, GSDMD is linked to systemic lupus erythematosus.