Specifically, 1-s.d unit higher Alzheimer’s disease (OR: 0.961; [95% CI 0.932 − 0.991]; FDR q − value = 2.01E−02), liver iron content (OR: 0.945; [95% CI 0.901 − 0.992]; FDR q − value = 2.18E−02), sex hormone binding globulin levels (OR: 0.852; [95% CI 0.737 − 0.986]; FDR q − value = 2.27E−02), and circulating leptin levels (OR: 0.818; [95% CI 0.682 − 0.981]; FDR q − value = 2.27E−02) were related to a decreased risk of PCs, while each 1-s.d unit higher naive CD4–CD8-T cell %T cell (OR: 1.156; [95% CI 1.030 − 1.296]; FDR q − value = 2.01E−02) was related to an increased risk of PCs (Fig. 4A). This evidence concerns the gene LEP and early-onset autosomal dominant Alzheimer disease.