ADH1B (OR = 0.15, 95% CI = 0.07–0.35), BMP1 (OR = 7.04, 95% CI = 3.35–14.78), and HIST1H3A (OR = 205.85,95%CI = 78.35–540.8) were found to be significantly associated with gout at the Bonferroni-corrected threshold (P 1.719 10 − 6) (Fig. 6, Additional file 8: Table S4). The gene discussed is ADH1B; the disease is gout.