Experimental data have demonstrated that knockdown of Sox9 attenuates the 7-HC suppressive effects on KIM-1 and reverse the 7-HC stimulatory effects on cyclin D1 expression in HK-2 cells treated with cisplatin, indicating that the AKI protective mechanism stimulated by 7-HC may be mediated through Sox9 [31]. This evidence concerns the gene SOX9 and acute kidney injury.