Previous study showed that ethanol extract of C. morifolium leaves attenuated hepatic steatosis in diet-induced mice model by downregulating the mRNA expression of lipogenic genes (Srebf1c, Srebf2, Fasn, Scd1, and Acaca) and upregulating Cpt1α [14], and chlorogenic acid attenuated fatty liver by up-regulating the gene expression of PPARα in diet-induced hypercholesterolemic rats [47]. This evidence concerns the gene ACACA and fatty liver disease.