As shown in Table 1, compared to those in the non-osteoporosis group, the osteoporosis group was more likely to be female; have a non-Hispanic White status; have a family PIR probability of 1.0–3.0; have never smoked; have a history of hypertension, diabetes, and hypercholesterolemia; be used hypotensive drugs, hypoglycemic drugs, and cholesterol-lowering drugs; have higher SBP, triglyceride, total cholesterol, HDL-C, BUN, FPG, HbA1c, CRP, ALP and total calcium values; and have lower BMI, DBP, albumin and uric acid values (p < 0.05). The gene discussed is ALB; the disease is Hypercholesterolemia.