Moreover, two previous studies demonstrated that the renin-angiotensin system (RAS) plays a significant role in osteoporosis, where the activation of the local RAS in bone tissue can lead to increased bone resorption, thereby triggering osteoporosis, and the use of RAS inhibitors can significantly reduce the incidence of osteoporosis and osteoporotic fractures [28, 29]. This evidence concerns the gene REN and osteoporosis.