Patients carrying pathologic variants of TARDBP gene (for TDP-43) are associated with increased rates of atrophy in the hippocampus, temporal pole and middle frontal gyrus, while FTD-TDP and AD-related TDP-43 proteinopathy are also associated with increased rates of atrophy in the inferior temporal lobe and amygdala [96]. Here, TARDBP is linked to frontotemporal dementia.