Another study in patients with LATE neuropathological changes (LATE-NC) found increased TDP-43 in astrocyte-derived EVs (ADEVs) but neither in NDEVs nor in microglial-derived EVs [79], suggesting a pivotal role of astrocytes in the pathogenesis of TDP-43 proteinopathy. Here, TARDBP is linked to proteostasis deficiencies.