Statins act as blockers of hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase and are able to reduce cholesterol synthesis, significantly lowering LDL cholesterol and Apo-B levels, in turn lowering serum triglyceride levels, and stabilizing and reversing plaques, thus, they are now becoming a fundamental drug in the fight against atherosclerosis and reduce the risk of cardiovascular disease [40, 41]. This evidence concerns the gene APOB and atherosclerosis.