Mechanically, the HECT domain of NEDD4L specifically binds to the Galx-β domain of ITGB4, which modifies the K915 site of ITGB4 through ubiquitination, and promotes the ubiquitination degradation of ITGB4, thus suppressing the malignant phenotype of esophageal carcinoma (Fig. 8). This evidence concerns the gene NEDD4L and carcinoma of esophagus.