ITGB4 and carcinoma of esophagus: Mechanically, the HECT domain of NEDD4L specifically binds to the Galx-β domain of ITGB4, which modifies the K915 site of ITGB4 through ubiquitination, and promotes the ubiquitination degradation of ITGB4, thus suppressing the malignant phenotype of esophageal carcinoma (Fig. 8).