Subsequently, based on the bioinformatics platform UbiBrowser, the esophageal carcinoma TCGA database and GEO database (GSE53625), we screened the ITGB4 protein, which was related to the progression of esophageal carcinoma, and could be degraded by NEDD4L-mediated ubiquitination. The gene discussed is NEDD4L; the disease is carcinoma of esophagus.