ITGB4 and carcinoma of esophagus: In order to validate the role of NEDD4L in promoting ITGB4 ubiquitination degradation in the growth and metastasis of esophageal carcinoma in vivo, we screened the high-NEDD4L expression ECA109 cells and the high-NEDD4L and high-ITGB4 expression ECA109 cells through the NEDD4L and ITGB4 high-expression lentivirus, and constructed the esophageal carcinoma tumor bearing and metastasis models.