From RNA-seq and DIA-MS data following GLUT1 silencing, both the transcriptional and translation levels were affected by GLUT1 suggested that GLUT1 is involved in the regulation of large genes or pathways in LUAD, such as Cell cycle, Pathways in cancer, TGF-beta and ubiquitin- ubiquitin-mediated proteolysis. The gene discussed is SLC2A1; the disease is cancer.