Another study by Xiangpei Yue et al. showed that IHT lowered the levels of pro-inflammatory cytokines IL-1β and IL-6 in APP/PS1 mice brains and diminished the expression of AD pathology-related genes, thus reducing β-secretase-mediated cleavage of APP and preventing Aβ overloading in the brain [54]. Here, APP is linked to Alzheimer disease.