Another neonatal diabetes gene containing a dDMR characterized by dramatic hypermethylation across pancreas development encodes the lipopolysaccharide responsive beige like anchoring protein (LRBA); DNA methylation at 44 of 118 (37.29%) LRBA sites was associated with developmental age (Fig. 5D), with these sites clustered into a discrete dDMR encompassing an intragenic CpG island (beta = 0.235, P = 1.14 × 10–301) (Fig. 5E and Supplementary Table 8). The gene discussed is LRBA; the disease is diabetes mellitus.