In parallel to these findings, other studies have also demonstrated the potent antiviral effect of STING induction through a RIG-1 agonist, namely 5’ triphosphorylated RNA (5’ pppRNA), which can increase STING induction both at transcriptional and translational levels following herpes simplex virus 1 (HSV), an enveloped dsDNA virus, infection [33]. The gene discussed is STING1; the disease is infection.