To fully illustrate and confirm the differential expression of SCGN in ccRCCs and normal kidney tissues, we analyzed RNA sequencing data using multiple databases, and we obtained consistent results in TCGA, CPTAC and GSE40435 cohorts that the transcript levels of SCGN were higher in ccRCC than in normal kidney (Fig. 1C–E). Here, SCGN is linked to nonpapillary renal cell carcinoma.