TLR7 then signals through Myd88 to interleukin-1 receptor-associated kinase 1/-4 (IRAK1/-4), leading to nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB) and type I interferon (IFN) expression programs that are typically associated with SLE6, but critically are required to fight viral infection. This evidence concerns the gene IRAK1 and viral infectious disease.