After seven days of OI, the OI group showed significantly greater RUNX2 (2.25-fold, P < 0.01), OCN (1.42-fold, P < 0.01) and Osterix (2.21-fold, P < 0.01) expression than the NC group (Fig. 4D). The gene discussed is RUNX2; the disease is osteogenesis imperfecta.