After 14 days of OI, the expression of RUNX2 (1.63-fold, P < 0.05), OCN (3.77-fold, P < 0.01) and Osterix (2.13-fold, P < 0.001) in the OI group was significantly greater than that in the NC group. This evidence concerns the gene SP7 and osteogenesis imperfecta.