SLC4A1 and neoplasm: In summary, utilizing this CEUS technique, we could successfully detect small tumors, as illustrated in Figure S1C. For example, a small PDAC tumor (highlighted by a yellow circle) was accurately identified from the image and validated through live sacrifice, H&E staining, and immunofluorescence staining using the pan-keratin marker AE1/AE3 (Fig. S1D–F).