MAPK14 and central nervous system cancer: To explore the targets of HNRNPC, we analyzed differentially expressed genes in glioma and normal brain tissues in TCGA database, as well as the prognostic value in HGGs and LGGs; three genes were finally obtained, including IRAK1, platelet derived growth factor subunit A (PDGFA), and mitogen-activated protein kinase kinase kinase 14 (MAP3K14) (Supplementary Fig. 3B, C, Supplementary Data 5, 6).