In addition, multivariate analysis revealed that HNRNPC overexpression was a significant independent prognostic indicator for OS in glioma (hazard ratio = 2.260, 95% confidence interval = 1.259–4.060, p = 0.0063) after adjusting for age, gender and the tumor grade (Fig. 1F). The gene discussed is HNRNPC; the disease is central nervous system cancer.