Hence, it can be concluded that these phenotypes are caused by the reduced expression of ASTN2. Moreover, given that this region of ASTN2, including the target site of CRISPR/Cas9 and the deleted region in SCZ3, is a disease-susceptible region (gray-shaded area in Fig. 1A) [17], these phenotypes will also reflect the vulnerabilities for the onset of psychiatric disorders at the cellular and molecular levels. The gene discussed is ASTN2; the disease is psychiatric disorder.