Among 65 patients with direct lung injury risk factors (pneumonia: 56; macro-aspiration: 7; inhalational injury: 4; pulmonary vasculitis: 1), we found no systematic difference of LRT galectin-3 levels when patients were stratified by the organisms isolated in clinical microbiologic cultures of LRT biospecimens (ETA or BAL) obtained as part of the diagnostic workup by the treating clinicians (Supplementary Fig. 8a). The gene discussed is LGALS3; the disease is pneumonia.