Similarly, we found that patients classified to the prognostically favorable hypoinflammatory subphenotype had higher LRT galectin-3 compared to patients classified to the prognostically adverse hyperinflammatory subphenotype (Fig. 6c) Stratified by 30-day survival, we found a highly significant correlation between LRT neutrophil elastase and galectin-3 in survivors only (Fig. 6d,r = 0.54, p < 0.0001), an effect that was also driven primarily by patients with ARDS, as well as patients classified to the hypoinflammatory subphenotype (Fig. 6e–f). This evidence concerns the gene ELANE and acute respiratory distress syndrome.