Among 65 patients with direct lung injury risk factors (pneumonia: 56; macro-aspiration: 7; inhalational injury: 4; pulmonary vasculitis: 1), we found no systematic difference of LRT galectin-3 levels when patients were stratified by the organisms isolated in clinical microbiologic cultures of LRT biospecimens (ETA or BAL) obtained as part of the diagnostic workup by the treating clinicians (Supplementary Fig. 8a). Here, LGALS3 is linked to susceptibility to pneumonia measurement.