LGALS3 and infection: As in all of our experiments, while both the WT and galectin-3 knockout (KO) mice infected by PA14 mice appeared sick and huddled by 4 h after infection, the galectin-3 KO LPS + PA14 mice also appeared sick and lethargic, unable to move when prompted unlike the WT LPS + PA14 mice, which did not display similar signs of morbidity.