ACSL4 and cancer: To explore the potential relevance of our findings in cancer, we analyzed the expression level of FADS2 in several cell lines of lung and kidney cancer cells and found that among them, A549 and 786-O cells exhibited robust expression of FADS2 (Fig. 6A) (for reference, expression levels of FADS1 and ACSL4 are shown in Supplementary Fig. 2B).