CXCL2 is a pro-inflammatory chemokine playing a role in the development of cardiovascular diseases (18, 23). The overexpression of CXCL2 can lead to vascular endothelial cell damage in blood vessels through the activation of neutrophils. Furthermore, CXCL2 plays a role in reorganization of the cytoskeleton, cell migration, adhesion, and immune response and is associated with atherosclerosis, diabetes, obesity, and myocardial infarction (23). The gene discussed is CXCL2; the disease is obesity due to melanocortin 4 receptor deficiency.