As observed above for AEP, a significant sleep × genotype interaction was observed for AT8, F(1,24) = 6.6; p < 0.05, along with main genotype, F(1,24) = 21.5; p < 0.0001, and sleep effects, F(1,24) = 5.7; p < 0.05 (Fig. 3A,B), where AT8 immunoreactivity was increased in LCn in CFS Dbh+, relative to rested Dbh+ mice, q = 5.2; p < 0.01, while no increase was observed for CFS Dbh− relative to rested Dbh− mice, q = 0.2, N.S. Consequently, LCn AT8 was greater in CFS Dbh+ mice, relative to CFS Dbh− mice, q = 7.6; p < 0.0001; Figure 3A,B. The gene discussed is DBH; the disease is myalgic encephalomeyelitis/chronic fatigue syndrome.