Sleep disruption in young adult wild-type mice for 1 week imparts metabolic injury to the locus ceruleus neurons (LCn; J. Zhang et al., 2014), while extended sleep disruption in young adult mice manifests as lasting neural injury, including injury to and loss of LCn and CA1 hippocampal neurons, and increased hippocampal Aβ42, p-tau, and glial reactivity (Owen et al., 2021), supporting the concept that CSD can influence AD-vulnerable neuronal groups and influence Aβ and tau homeostasis, irreversibly and in the absence of a genetic predisposition to AD pathology. Here, MAPT is linked to Alzheimer disease.