Specifically, AEP-APP was higher in CFS Dbh+ mice than that in any of the other groups: rested Dbh+ (q = 7.0; p < 0.001), rested Dbh− (q = 6.1; p < 0.001) and CFS Dbh− mice (q = 4.1; p < 0.05; Fig. 4A,D). The gene discussed is APP; the disease is myalgic encephalomeyelitis/chronic fatigue syndrome.