Sleep was equally fragmented in Dbh−/− and control male and female mice, yet only Dbh−/− mice conferred resistance to CFS loss of LCn, LCn p-tau, and LCn AEP upregulation and activation as evidenced by an increase in AEP-cleaved APP and tau fragments. The gene discussed is MAPT; the disease is myalgic encephalomeyelitis/chronic fatigue syndrome.