CXCL8 and cancer: At the cellularlevel, plastic exposure impacts numerous gene expression pathwayslinked to inflammatory signaling and cancer, including NF-κB,52 IL-6 53, TNF alpha,53 and IL-8 (CXCL8).54 Consistentwith these observations, our analyses revealed several dysregulationsof these key genes by all classes of additives (Table S2).