Both P-tau species were significantly increased in DLB (P-tau181: β = 0.368, 95% CI 0.245–0.491, p < 0.001; P-tau231: β = 0.379, 95% CI 0.242–0.517, p < 0.001) and AD (P-tau181: β = 0.579, 95% CI 0.437–0.720, p < 0.001; P-tau231: β = 0.635, 95% CI 0.476–0.793, p < 0.001) compared with HC, and higher in AD compared with DLB (P-tau181: β = 0.211, 95% CI 0.106–0.315, p < 0.001; P-tau231: β = 0.2552, 95% CI 0.138–0.372, p < 0.001). The gene discussed is MAPT; the disease is Lewy body dementia.