The P-tau species were significantly increased in DLB A− (P-tau181: β = 0.272, 95% CI 0.065–0.479, p < 0.01; P-tau231: β = 0.274, 95% CI 0.044–0.504, p < 0.05) and DLB A+ (P-tau181: β = 0.518, 95% CI 0.308–0.728, p < 0.001; P-tau231: β = 0.478, 95% CI 0.242–0.714, p < 0.001) compared with HC, and significantly lower in DLB A− compared with AD (P-tau181: β = −0.304, 95% CI −0.496 to −0.111, p < 0.001; P-tau231: β = −0.359, 95% CI −0.573 to −0.145, p < 0.001). The gene discussed is MAPT; the disease is Alzheimer disease.