Fig 1B shows that HOXA 11 and HOXD3 mRNA expression was similar in FLS derived from either joint (n = 4). However, several HOX genes were more highly expressed in RA knee FLS compared with knee FLS, including HOXA11, HOXD9, HOXD10, HOXA11-AS. Of these, HOXD10 showed the greatest difference and was 85±20-fold higher in RA knee FLS compared to hip FLS (P = 0.009). The gene discussed is HOXA11; the disease is rheumatoid arthritis.