In addition, We divided the patients into high and low groups according to the expression of POLD4 and evaluated the survival prognosis of GBM patients by Kaplan–Meier survival curve analysis, and the disease-free survival and overall survival of patients with high POLD4 expression was meaningly shorter both in both the CGGA and TCGA datasets than those with low expression. This evidence concerns the gene POLD4 and glioblastoma.