Studies have shown that Tmem16A (Anoctamin 1), a Ca2+ regulated anion channel, is involved in regulating baseline mucus release in the mouse distal colon; however, whether other anion transporters such as the anion exchanger slc26a3 (down-regulated in adenoma (DRA)) is involved in regulating other aspects of mucus layer formation such as expansion of the mucus following exocytosis or regulates de novo mucus secretion in response to secretagogues is not known [4]. This evidence concerns the gene ANO1 and adenoma.