Chédeville et al. [58] revealed that hypoxia-induced upregulation of LDHA in glioblastoma triggers a glycolytic shift accompanied by enhanced expression of pro-angiogenic factors, including VEGFA, with high expression levels of genes, such as SLC2A1, LDHA, PDK1, PFKFB4, HK2, VEGFA, SERPINE1, TFRC, and ADM significantly associated with decreased survival rates. This evidence concerns the gene PFKFB4 and glioblastoma.