PDGFRB and nonpapillary renal cell carcinoma: In a study by Yang et al. [17], the inactivation of von Hippel–Lindau (VHL) in clear cell renal cell carcinoma (ccRCC) was found to trigger histone lactylation, establishing a positive feedback loop with platelet-derived growth factor receptor beta (PDGFRβ) signaling that promotes ccRCC progression.