HK2 and cancer: Similarly, it waspreviously reported that hexokinase 2 (HK2), a key glycolytic enzyme upregulated invarious cancer cells (Shinohara et al.,1994; Mathupala et al., 2001; Patra et al., 2013) and required for oncogenictransformation and tumor development (Patraet al., 2013), undergoes degradation through CMA(Xia et al., 2015).