Silencing of Gal3and c-Abl/Arg rendered MCF7 cells more susceptible to apoptosis, resulting inreduced tumor growth (Li et al., 2010).Likewise, the epidermal growth factor receptor pathway substrate 8 (Eps8),implicated in tumor promotion and metastasis, was proposed as a CMA substrate inhuman cancer cells (Welsch et al.,2010). Here, EPS8 is linked to cancer.