NFE2L2 and neoplasm: Additionally, the existing evidencesuggests that the application of antioxidants can, to some extent or entirely,reverse or modulate autophagy, emphasizing the role of CMA in the elimination ofoxidized proteins (Levonen et al., 2014).NRF2 (nuclear factor erythroid 2-related factor 2) is a protein that plays a pivotalrole in regulating the cellular response to stress, especially oxidative stress, aprimary form of stress to which tumor cells are subjected.