Interestingly, mutation in the coding region of STYXL2 and abnormal CpG methylation at the STYXL2 locus were detected in some patients with congenital heart defects (CHD), suggesting a possible link of STYXL2 to CHD (Arrington et al., 2012; Radhakrishna et al., 2016). This evidence concerns the gene STYXL2 and coronary artery disorder.