This analysis demonstrated differences in IL-17A regulation between non-PSC and PSC ECO, which is noted by the identification of pathways such as coronavirus pathogenesis, PKR in interferon induction, hepatic fibrosis, and IL-13 signaling in PSC ECO only (Supplemental Figure S3, Supplemental Digital Content 1, http://links.lww.com/HC9/A900). The gene discussed is IL17A; the disease is Hepatic fibrosis.