IL17A and liver disorder: In PSC, recent human studies have proficiently identified IL-17A within liver tissue sections, demonstrating a discernible increase in IL-17–producing cells in periductal regions among patients with PSC when compared to control subjects25, 26, 27 and compelling findings suggest that secretion of IL-17A by peripheral blood mononuclear cells (PBMCs), is elevated in individuals with PSC compared to those with other inflammatory liver diseases.26