CD8A and liver disorder: IL-17A is prominently expressed in human diseases and has been broadly studied, therefore it is considered to be the main inducer of the IL-17 signaling pathway.17, 18 It shares a great percentage of conservation with IL-17F and it is produced predominantly by a T-cell subset termed Th17 cells.18, 19 IL-17A can be secreted by other cell types, including γδ T-cells, mucosal-associated invariant T cells, CD8+ T-cells and neutrophils in the liver.20, 21, 22 Th17 cells and IL-17+ CD8+ T-cells are considered, however, the major source of IL-17 in several inflammatory liver diseases.23