EFEMP1 and metabolic dysfunction-associated steatotic liver disease: Other reports have also shown that EFEMP1 is one of the genes that is markedly upregulated in the liver of patients with NAFLD with advanced fibrosis.43, 44 And EFEMP1-expressing cells in NAFLD liver have been reported to be hepatocytes, vascular endothelial cells, and fibroblasts.44