Hyaluronic acid, type IV collagen 7S, and M2BPGi are reported to be fibrosis markers useful for differentiating NAFLD from advanced fibrosis.35, 36 According to our multivariate analysis that included these factors, higher serum Fibulin-3 levels were identified as an independent risk factor for the occurrence of liver-related events in patients with MASLD, in addition to a higher FIB-4 index. Here, EFEMP1 is linked to metabolic dysfunction-associated steatotic liver disease.