Notably, this is almost an order of magnitude lower than the concentration typically used for CD47 blocking Abs and recombinant SiRPα-Fc proteins (28) and likely explains the detection of T cell–secreted CV1-Fc but not wtSiRPα-Fc binding to CD47+ tumor cells (Figure 3G and Supplemental Figure 3E) from culture supernatants. The gene discussed is CD47; the disease is neoplasm.