Although we used an orthotopic intracranial xenograft model injected with NHA/HRasV12/TRIM24 cells to monitor clinical Ep‐GBM‐like tumor generation and progression, it is difficult to obtain fresh clinical tumor samples from patients with Ep‐GBM to establish patient‐derived xenograft (PDX) models or generate organoids to recapitulate clinical Ep‐GBM tumors. Here, TRIM24 is linked to glioblastoma.