Hematoxylin‐eosin (H&E) staining analysis revealed that, compared to NHA/HRasV12/EV tumors, the tumor cytology in NHA/HRasV12/TRIM24‐derived tumors presented as a high‐grade glioma with heteromorphic large epithelioid cells with abundant eosinophilic cytoplasm, a high degree of nuclear atypia, and laterally positioned melanoma‐like nuclei. Here, TRIM24 is linked to central nervous system cancer.