TRIM24 is an epigenetic regulator of cancer progression in various cancers.[18, 67, 68] We previously reported that TRIM24 functions as a transcriptional co‐activator of STAT3 in EGFR‐driven GBM tumorigenesis.[22] In this study, we demonstrate that TRIM24 has a novel function associated with snoRNAs. The gene discussed is STAT3; the disease is cancer.