To elucidate the possible pathways TRIM24‐activated that may be involved in AA transformation toward Ep‐GBM, we performed KEGG pathway analysis and GSEA analysis of these 1104 upregulated genes and found that multiple pathways were highly activated in the NHA/HRasV12/TRIM24 cells, such as the TNF, MAPK, and PPAR signaling pathway (Figure 3B,C; Figure S3A, Supporting Information). Here, TRIM24 is linked to glioblastoma.