Since RAS‐RAF‐MEK‐ERK and RAS‐PI3K‐AKT‐ mTOR act as fundamental signaling pathways for RAS proteins,[48, 49, 50] we determined whether the PI3K inhibitor LY294002, the MEK inhibitor U0126, or the mTOR inhibitor rapamycin could impair TRIM24‐induced Ep‐GBM‐like transformation. The gene discussed is MTOR; the disease is glioblastoma.