TP53 and central nervous system neoplasm: These data suggest that NHA/HRasV12/TRIM24‐derived tumors resemble Ep‐GBM in the clinical diagnostic criteria of Ep‐GBM summarized in the 2016 WHO Classification of CNS Tumors and previously reported descriptions of Ep‐GBM.[31, 37, 38, 39] To further validate the ability of TRIM24 to induce Ep‐GBM‐like formation in vivo, we co‐transfected lentivirus‐mediated HRasV12 mutant and HA‐TRIM24 into hNSC‐TP53 shRNA (hNSC/shTP53) cells (Figure 1I).