In summary, we demonstrated that PD‐L1 is heterogeneously expressed in NF2‐associated meningiomas, the PI3K–AKT–mTOR pathway regulates its expression, and targeting PD‐L1 could be helpful for recovering the function of tumor‐infiltrating lymphocytes and inducing apoptosis to inhibit tumor proliferation. This evidence concerns the gene NF2 and meningioma.