In this study, we detected the expression of PD‐L1 in NF2‐associated meningiomas, explored the effect of PD‐L1 downregulation on tumor cell characteristics and T‐cell functions, and investigated the possible pathways that regulate PD‐L1 expression to further dissect the possible mechanism of immune suppression in NF2 tumors and to provide new treatment options for NF2 patients. Here, NF2 is linked to NF2-related schwannomatosis.