The results show that when T cells were cocultured with siPD‐L1‐transfected NF2‐associated meningioma cells, the expression of CD69 on both CD4+ and CD8+ T cells was partly restored, and the capacity of T cells to kill siPD‐L1‐transfected tumor cells was partly recovered, suggesting that targeting PD‐L1 could promote T‐cell activation, prevent tumor‐immune escape and help T cells kill tumor cells in NF2‐associated meningioma. The gene discussed is CD8A; the disease is meningioma.