Multivariate logistic regression analyses further revealed that high GDF-15 levels (p = 0.020) and diabetes (p = 0.034) were independently correlated with increased cardiotoxicity risk; in addition, advanced age (p = 0.052) tended to be independently correlated with increased cardiotoxicity risk, but the correlation was not statistically significant. This evidence concerns the gene GDF15 and diabetes mellitus.