SMAD4 and Hepatic fibrosis: Consistently, in this study we observed that SnoN expression markedly decreased after BDL and CCl4 treatment in association with decreased formation of SnoN/Smad4 complexes, increased TGFβ/Smad signaling, and liver fibrosis, whereas LP340 increased SnoN and inhibited hepatic fibrosis after BDL and CCl4 treatment (Figure 5; Figure 10).