ACE and Hepatic fibrosis: Many antifibrotic treatments targeting various fibrotic pathways have been assessed in liver fibrosis, such as angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, interferon, pioglitazone, colchicine, farglitazar, simtuzumab, non-coding RNAs, pegbelfermin, natural herbs, and transplantation of stem cells (Friedman, 2015; Rockey et al., 2015; Trautwein et al., 2015).