ITPR2 and hydrops fetalis: In addition to inducing mitophagy, FUNDC1 has a critical role in the maintenance of normal mitochondrial morphology and function in cardiomyocytes, interacting with inositol-1,4,5-triphosphate receptor 2 (IP3R2) in modulating Ca2+ release from the endoplasmic reticulum (ER) into the mitochondria and cytoplasm, and disruption of its interaction decreases Ca2+ levels in the mitochondria and cytoplasm, triggering abnormal mitochondrial fission, mitochondrial dysfunction, cardiac dysfunction, and HF (Wu et al., 2017a).