Utilizing Beclin1+/−, FUNDC1 gene knockout, and FUNDC1 transgenic mice combined with starvation and MI model, it was found that after MI, the FUNDC1 knockout group caused more severe mitochondrial and cardiac dysregulation than the Beclin1+/− group, suggesting that mitophagy but not macroautophagy promotes cardioprotection primarily by regulating mitochondrial function (Xu et al., 2022). Here, FUNDC1 is linked to myocardial infarction.