Lack of FUNDC1 decreases IP3R2 and Ca2+ levels in mitochondria and cytoplasm and reduces mitochondrial dysfunction, cardiac dysfunction, and HF by inhibiting Ca2+-sensitive CREB-mediated fission 1(FIS1) expression (Wu et al., 2017a; Zhang et al., 2018). The gene discussed is ITPR2; the disease is hydrops fetalis.