FUNDC1-mediated mitophagy is also regulated by other factors, such as activation of the AMPKα1/ULK1/FUNDC1/mitophagy pathway can attenuate cardiac microvascular IRI, and a study on the Danqi pill also showed that Danqi pill could enhance FUNDC1-mediated mitophagy by modulating ULK1 and PGAM5 to protect HF after acute MI (Wang et al., 2022b; Cai et al., 2022). The gene discussed is ULK1; the disease is hydrops fetalis.