The same results were seen with baseline genetic ablation of FUNDC1, as evidenced by reduced early to late ventricular filling velocity, prolonged left ventricular isovolumic diastole, and reduced ejection fraction in mice and these phenotypic alterations suggest that FUNDC1 knockout mice are susceptible to HF (Wu et al., 2017a; Zhu et al., 2021). This evidence concerns the gene FUNDC1 and hydrops fetalis.