Here, we further demonstrated that CBS is highly expressed in KYSE450, NEC, MCF7, A549 and HCT8 cells (Figure 1A) and downregulation of CBS (Figure 1A) has been shown to inhibit tumor cell migration and invasion, as well as suppress angiogenesis and lymphangiogenesis (Figures 1B–E) in KYSE450, A549 and HCT8 cells. This evidence concerns the gene CBS and neoplasm.