Additionally, Jun et al. (Jun et al., 2021) revealed that BPA exposure significantly enhances the proliferation, migration, and tumor growth in human colon cancer cells through ERK pathway activation, E-cadherin expression reduction, and 5-HT3 receptors upregulation, suggesting a potential link between BPA exposure and colon cancer development. This evidence concerns the gene CDH1 and malignant colon neoplasm.