Meanwhile, a study by Song et al. describes a different approach, finding that sirtuin-1 improves atherosclerosis by regulating the acetylation of certain functional proteins, and treatment with H2S enhances its expression, deacetylation function, and stability, ultimately inhibiting the development and progression of CHD (Du et al., 2019; Song et al., 2023). Here, SIRT1 is linked to atherosclerosis.