Elevated expression of STAT1 and STAT3 in minor salivary gland biopsies from pSS patients, as well as in their blood samples, has been correlated with activation triggered by a range of immune mediators, including IFN-α, IFN-γ, IL-6, IL-17, and IL-22 (Wakamatsu et al., 2006; Ciccia et al., 2012). This evidence concerns the gene IL22 and peeling skin syndrome.