Emerging data from these models suggest a protective role of TNF in SS, as TNF deficiency exacerbates SS-like disease, the absence of TNF in certain models associated with inflammation within salivary glands and altered marginal B cell compartments, which might contributes to lymphoid tumors resembling MALT-L (Nocturne et al., 2021). This evidence concerns the gene TNF and synovial sarcoma.