Fatigue in SS correlates with factors like IL-1, IL-36α, and humoral autoimmunity-related components (Zeng et al., 2022), while inversely correlating with pro-inflammatory cytokines, including IFN-γ, TNF-α, lymphotoxin α, and CXCL10 (Davies et al., 2019). This evidence concerns the gene TNF and synovial sarcoma.