Ongoing explorations of anti-BAFF drugs for anxiety and selective serotonin reuptake inhibitors for depression are underway, considering factors like IL-1, IL-36α, and humoral autoimmunity in SS-related fatigue (Schlesinger et al., 2011; Vivino et al., 2016; Bodewes et al., 2019), with recent studies revealing an inverse correlation between fatigue intensity and pro-inflammatory cytokines, including IFN-γ, TNF-α, lymphotoxin α, and CXCL10 (Davies et al., 2019). Here, TNFSF13B is linked to depressive disorder.