Ling et al. found that the paeonol-platinum (II) complex promoted apoptosis of thyroid cancer cells, increased the fraction of sub-G1 cells, increased the expression of p27 and p21, downregulated p53 and cyclin D1, and inactivated the mTOR pathway in thyroid cancer cells (He et al., 2020). The gene discussed is TP53; the disease is thyroid gland carcinoma.