Ling et al. found that the paeonol-platinum (II) complex promoted apoptosis of thyroid cancer cells, increased the fraction of sub-G1 cells, increased the expression of p27 and p21, downregulated p53 and cyclin D1, and inactivated the mTOR pathway in thyroid cancer cells (He et al., 2020). This evidence concerns the gene TP53 and thyroid cancer.