After adjusting for multiple factors, the FGF21 incremental area under the curve (iAUC) was linearly correlated with the FFA iAUC, TG iAUC, and IL-6 iAUC (<i>P</i> < 0.05) and was an independent factor for MAFLD (<i>P</i> < 0.05, OR=1.403).<h4>Conclusion</h4>Dyslipidemia and excessive inflammation in MAFLD are associated to FGF21 levels in the postprandial period. This evidence concerns the gene IL6 and metabolic syndrome.