We are conscious of some limitations of this work: (i) functional studies of PvSDP1 using heterologous expression in P. falciparum, might not reveal is solely function in natural infections; (ii) the heterogeneity of human plasma EVs is always a confounding factor; yet, the use of immunocaptured CD71+-EVs increases the specificity of reticulocyte-derived EVs; (iii) Single-cell RNA experiments were limited to hSFs requiring future experiments with other spleen cells. The gene discussed is TFRC; the disease is infection.