GJB3 and erythrokeratodermia variabilis: EKVP is characterized by fixed hyperkeratotic plaques and transient erythematous patches and is mostly inherited in an autosomal dominant inheritance but homozygous GJB3 mutations also lead to EKVP in some rare cases, suggesting an autosomal recessive inheritance (Gottfried et al., 2002; He et al., 2005; Terrinoni et al., 2010; Zhang et al., 2022).