GJB2 and KID syndrome: Building on this approach, Lee et al. developed AS-siRNAs and applied them to an immortalized KID syndrome cell line (KID-KCs) derived from a patient harboring a heterozygous Cx26-D50N mutation, the most prevalent KID syndrome-associated mutation in the GJB2 gene, leading to aberrant hemichannel function (Lee et al., 2020).