In addition to Cx26, mutations in GJB6, GJB4, GJB3 and GJA1, encoding Cx30, Cx30.3, Cx31 and Cx43, respectively have also been linked to diverse epidermal diseases (Avshalumova et al., 2014; Laird and Lampe, 2022). Here, GJB3 is linked to epidermal disease.