Thus, the dysregulated molecular exchange across the plasma membrane through hyperactive hemichannels may be a common feature, underlying the epidermal phenotypes in Cx26 KID syndrome mutations (Kelsell et al., 2001; Stong et al., 2006; Gerido et al., 2007; Jonard et al., 2008; Sanchez and Verselis, 2014; Taki et al., 2018). The gene discussed is GJB2; the disease is KID syndrome.