They also identified 12 putative Wnt/-catenin signaling pathway targeted genes, such as AARSD1, HOXB5, ITGA6, LRRC71, MED19, MED24, METTL11B, SMARCB1, SMARCE1, TAF6L, TENT5A and ZNF281, from densely coupled glioma functional modules (62). Here, HOXB5 is linked to central nervous system cancer.