The present systematic review discusses the uses of AI in glioma detection, grading, the prediction of the isocitrate dehydrogenase (IDH) genotype, O6-methylguanine-DNA-methyltransferase (MGMT) promoter methylation status, 1p19q codeletion, survival prediction, treatment response, pseudo-progression and progression, and the glioma functional network. This evidence concerns the gene MGMT and glioma.